Ipamorelin
A selective pentapeptide ghrelin receptor agonist studied for its targeted activity in growth hormone secretagogue research with minimal off-target signaling. Its high selectivity makes it a preferred tool in studies requiring isolated GHS-R activation without cortisol or prolactin elevation.
Ipamorelin Overview
Ipamorelin is a pentapeptide originally developed within the growth hormone secretagogue class and is commonly described as a selective ghrelin receptor agonist. In research settings, it is used to examine receptor-mediated endocrine signaling and how ghrelin-pathway activation influences pituitary and metabolic system activity.
Mechanism of Action & Applications
Ipamorelin is studied for agonist activity at the growth hormone secretagogue receptor, also known as the ghrelin receptor or GHSR1a. In laboratory research, this makes it useful for examining receptor activation, intracellular signaling, pituitary hormone pathway dynamics, and broader ghrelin-related endocrine biology. It is commonly used in studies involving ghrelin receptor pharmacology, growth hormone secretagogue signaling, peptide-receptor selectivity, and neuroendocrine pathway research.
Research History
Ipamorelin emerged from medicinal chemistry efforts to develop growth hormone secretagogues with a more selective signaling profile. A 1998 paper described it as the first selective growth hormone secretagogue and identified its pentapeptide sequence as Aib-His-D-2-Nal-D-Phe-Lys-NH2, which helped distinguish it from earlier compounds in the same class.
Chemical Information
- CAS Number
- 170851-70-4
- Molecular Formula
- C38H49N9O5
- Molecular Weight
- 711.9 g/mol
- PubChem ID
- 9831659
For research use only. Not for human or veterinary use. Detailed storage guidelines →
Often Paired With
Researchers who buy Ipamorelin commonly stock these alongside it.
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Researcher Reviews
