Melanotan I
A linear melanocortin receptor agonist studied in research on melanogenesis, UV-response signaling, and melanocyte-stimulating hormone pathway activity. It is primarily used in laboratory models examining MC1R activation and downstream pigmentation-related gene expression.
Melanotan I Overview
Melanotan I, also known as afamelanotide or NDP-α-MSH, is an α-MSH analogue studied in research involving melanocortin signaling. In laboratory settings, it is used to examine how melanocortin receptor activity affects pigment-related cellular responses and broader melanocortin pathway biology.
Mechanism of Action & Applications
Melanotan I is studied for agonist activity at melanocortin receptors, with predominant activity described at MC1R. In research models, this makes it useful for examining melanogenesis-related signaling, receptor pharmacology, redox-associated melanocortin biology, and broader peptide-receptor interactions within the melanocortin system.
Research History
Melanotan I emerged from efforts to develop stable α-MSH analogues with longer-lasting melanocortin receptor activity than native hormone signaling. Earlier published work in the 1990s examined Melanotan I in biologic systems, and later development continued under the name afamelanotide.
Chemical Information
- CAS Number
- 75921-69-6
- Molecular Formula
- C78H111N21O19
- Molecular Weight
- 1,646.85 g/mol
- PubChem ID
- 16197727
For research use only. Not for human or veterinary use. Detailed storage guidelines →
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