Kisspeptin

Kisspeptin Overview

Kisspeptin refers to a group of peptide fragments encoded by the KISS1 gene that act as endogenous ligands for the kisspeptin receptor, also known as KISS1R. In research settings, it is studied for its role in neuroendocrine signaling and for how receptor activation influences downstream reproductive hormone pathways.

Mechanism of Action & Applications

Kisspeptin is studied for agonist activity at KISS1R, a G protein-coupled receptor. Published research describes KISS1R signaling primarily through Gq/11-linked pathways, with more recent work also identifying Gi/o coupling in some systems. In laboratory research, this makes kisspeptin useful for examining GnRH-related signaling, reproductive axis regulation, receptor trafficking, intracellular calcium responses, and broader neuroendocrine pathway activity.

Research History

Research on kisspeptin grew from the discovery of KISS1 as a metastasis suppressor gene and the later identification of kisspeptin peptides as ligands for KISS1R. Over time, investigation expanded into reproductive biology, where kisspeptin signaling became widely studied as a key upstream regulator of GnRH pathway activity and pubertal neuroendocrine signaling.

Chemical Information

CAS Number

374675-21-5

Molecular Formula

C₆₃H₈₃N₁₇O₁₄

Molecular Weight

1,302.4 g/mol

PubChem ID

25240297

Compound

Kisspeptin

Selected quantity

10 MG per vial

Research area

Reproductive & Hormonal

Intended use

Laboratory research only

Laboratory storage & handling

Form

Lyophilized powder

Short-term

2–8 °C (refrigerated)

Long-term

−20 °C (frozen)

Container

Use the supplied container and follow its label

Lot-specific stability

Not established on this product page

Reconstitution

Consult the applicable research protocol and available lot record

For research use only. Not for human or veterinary use.

A certificate for Kisspeptin 10 MG has not been published yet. Records are published per lot as they are received; a missing record is not a test result.

Use the lot number on your vial to locate the corresponding certificate once it is available, or contact support for batch documentation.

Orders placed by 2 PM PST typically ship the same business day; later orders ship the next business day. U.S. fulfillment with tracking sent by email once your order is on its way.

Complimentary standard shipping on orders over $200. Express and overnight options are offered at checkout.