Mazdutide

Mazdutide Overview

Mazdutide, also known as IBI362, is an oxyntomodulin-based peptide studied for dual activity across GLP-1 and glucagon receptor pathways. In research settings, it is used to examine how these two receptor systems work together and how combined receptor activity influences broader metabolic and endocrine signaling.

Mechanism of Action & Applications

Mazdutide is studied as a dual agonist at the GLP-1 and glucagon receptors. This receptor profile allows researchers to examine how simultaneous activation of incretin- and glucagon-related pathways affects intracellular signaling, energy balance regulation, and broader metabolic system responses. It is commonly used in research involving incretin biology, glucagon receptor signaling, metabolic pathway coordination, and dual-receptor peptide design.

Research History

Mazdutide emerged from efforts to develop dual GLP-1/glucagon receptor agonists based on oxyntomodulin-related peptide design. Published phase 1b and phase 2 studies later expanded its characterization in controlled research settings, helping establish it as a notable dual-agonist peptide within metabolic pathway research.

Chemical Information

CAS Number

2259884-03-0

Molecular Formula

C₂₀₇H₃₁₇N₄₅O₆₅

Molecular Weight

4,477.14 g/mol

PubChem ID

167312357