IGF-1 LR3

IGF-1 LR3 Overview

IGF-1 LR3, also known as Long R3 IGF-1, is an 83-amino-acid analogue of insulin-like growth factor 1. It differs from native IGF-1 by an arginine substitution at position 3 and a 13-amino-acid N-terminal extension, changes that have been used in research to study altered receptor interaction, reduced binding to IGF-binding proteins, and extended activity in experimental systems.

Mechanism of Action & Applications

IGF-1 LR3 is studied for its activity at the IGF-1 receptor, where receptor engagement is used to examine intracellular signaling related to growth, survival, and metabolic regulation. Because this analogue has reduced affinity for IGF-binding proteins compared with native IGF-1, it is commonly used in research involving receptor signaling duration, cell growth pathways, anabolic signaling models, and IGF-axis biology.

Research History

Research on IGF-1 LR3 developed from broader work on insulin-like growth factor biology and the role of IGF-binding proteins in regulating peptide availability. Longer-chain analogues such as LR3 were designed to help researchers study how structural modifications change receptor activity, binding-protein interaction, and functional persistence in laboratory models.

Chemical Information

CAS Number

946870-92-4

Molecular Formula

C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉

Molecular Weight

9,117.60 g/mol

Compound

IGF-1 LR3

Selected quantity

1 MG per vial

Research area

Musculoskeletal & Growth

Intended use

Laboratory research only

Laboratory storage & handling

Form

Lyophilized powder

Short-term

2–8 °C (refrigerated)

Long-term

−20 °C (frozen)

Container

Use the supplied container and follow its label

Lot-specific stability

Not established on this product page

Reconstitution

Consult the applicable research protocol and available lot record

For research use only. Not for human or veterinary use.

A certificate for IGF-1 LR3 1 MG has not been published yet. Records are published per lot as they are received; a missing record is not a test result.

Use the lot number on your vial to locate the corresponding certificate once it is available, or contact support for batch documentation.

Orders placed by 2 PM PST typically ship the same business day; later orders ship the next business day. U.S. fulfillment with tracking sent by email once your order is on its way.

Complimentary standard shipping on orders over $200. Express and overnight options are offered at checkout.