ARA-290

ARA-290 Overview

ARA-290, also known as cibinetide, is an 11-amino-acid peptide derived from the helix B surface of erythropoietin. In research settings, it is studied for selective activity at tissue-protective receptor systems rather than classical erythropoietic signaling, making it a useful compound for examining repair-associated and stress-response pathways at the cellular level.

Mechanism of Action & Applications

ARA-290 is studied for selective signaling at the non-hematopoietic erythropoietin receptor complex, often described as a receptor system involving EPOR and the beta common receptor (CD131). In laboratory research, this makes it useful for examining tissue-protective signaling, inflammatory pathway modulation, cellular stress responses, and receptor activity linked to non-erythropoietic erythropoietin biology. It is commonly used in studies involving inflammatory signaling, neuropathic pathway models, metabolic stress biology, and broader cell-protection research.

Research History

ARA-290 emerged from efforts to isolate the tissue-protective properties of erythropoietin without reproducing its red blood cell stimulating effects. This led to the development of smaller erythropoietin-derived peptides such as cibinetide, which were then studied in preclinical and clinical research models involving inflammatory, metabolic, and neurologic pathway activity.

Chemical Information

CAS Number

1208243-50-8

Molecular Formula

C₅₁H₈₄N₁₆O₂₁

Molecular Weight

1,257.31 g/mol

PubChem ID

91810664

Compound

ARA-290

Selected quantity

10 MG per vial

Research area

Neuropeptides & Immunology

Intended use

Laboratory research only

Laboratory storage & handling

Form

Lyophilized powder

Short-term

2–8 °C (refrigerated)

Long-term

−20 °C (frozen)

Container

Use the supplied container and follow its label

Lot-specific stability

Not established on this product page

Reconstitution

Consult the applicable research protocol and available lot record

For research use only. Not for human or veterinary use.

A certificate for ARA-290 10 MG has not been published yet. Records are published per lot as they are received; a missing record is not a test result.

Use the lot number on your vial to locate the corresponding certificate once it is available, or contact support for batch documentation.

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