Retatrutide

Retatrutide Overview

Retatrutide is a multi-receptor peptide studied for activity across GLP-1, GIP, and glucagon pathways. In research settings, it is used to examine how these receptor systems work together and how combined receptor activity influences broader metabolic and endocrine signaling.

Mechanism of Action & Applications

Retatrutide is studied as a triple agonist at the GLP-1, GIP, and glucagon receptors. This receptor profile allows researchers to examine how simultaneous activation of incretin- and glucagon-related pathways affects intracellular signaling, hormone pathway coordination, and broader metabolic system responses. It is commonly used in research involving metabolic signaling, incretin receptor biology, multi-hormone pathway activity, and endocrine system regulation.

Research History

Retatrutide builds on earlier incretin research that first focused on GLP-1 receptor activity, then expanded to dual GLP-1/GIP agonists. Later development introduced glucagon receptor activity into the same peptide framework, leading to triple-agonist compounds like Retatrutide for more integrated pathway research.

Chemical Information

CAS Number

2381089-83-2

Molecular Formula

C₂₂₁H₃₄₂N₄₆O₆₈

Molecular Weight

4,845.44 g/mol

PubChem ID

474492335