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Cellular & Longevity

MOTS-c

$50Per vial

A mitochondrial-derived peptide studied in research on metabolic regulation, AMPK pathway activation, and exercise-mimetic signaling in cellular models. It is one of the few known mitochondrial-encoded peptides with direct effects on nuclear gene expression and metabolic homeostasis.

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Batch record published · 99.21%

Lot P1P-MOT10-001 · Freedom Diagnostics

For laboratory research only. Not for human or veterinary use.

About MOTS-c

MOTS-c Overview

MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA region. In research settings, it is studied as a mitochondrial-derived signaling peptide involved in metabolic regulation, cellular stress adaptation, and energy-related pathway biology.

Mechanism of Action & Applications

MOTS-c is commonly studied for its involvement in the folate-AICAR-AMPK pathway and related metabolic signaling networks. In laboratory research, this makes it useful for examining cellular energy sensing, mitochondrial signaling, metabolic stress responses, and broader pathway coordination linked to exercise, aging, and metabolic regulation models.

Research History

Research on MOTS-c expanded rapidly after its initial characterization as a mitochondrial-derived peptide in 2015. Since then, it has been studied across a range of metabolic and aging-related research models, helping establish mitochondrial-derived peptides as an important area of cellular signaling research.

Chemical Information

CAS Number
1627580-64-6
Molecular Formula
C101H152N28O22S2
Molecular Weight
2,174.6 g/mol
PubChem ID
146675088

Researcher Reviews