MOTS-c
A mitochondrial-derived peptide studied in research on metabolic regulation, AMPK pathway activation, and exercise-mimetic signaling in cellular models. It is one of the few known mitochondrial-encoded peptides with direct effects on nuclear gene expression and metabolic homeostasis.
MOTS-c Overview
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA region. In research settings, it is studied as a mitochondrial-derived signaling peptide involved in metabolic regulation, cellular stress adaptation, and energy-related pathway biology.
Mechanism of Action & Applications
MOTS-c is commonly studied for its involvement in the folate-AICAR-AMPK pathway and related metabolic signaling networks. In laboratory research, this makes it useful for examining cellular energy sensing, mitochondrial signaling, metabolic stress responses, and broader pathway coordination linked to exercise, aging, and metabolic regulation models.
Research History
Research on MOTS-c expanded rapidly after its initial characterization as a mitochondrial-derived peptide in 2015. Since then, it has been studied across a range of metabolic and aging-related research models, helping establish mitochondrial-derived peptides as an important area of cellular signaling research.
Chemical Information
- CAS Number
- 1627580-64-6
- Molecular Formula
- C101H152N28O22S2
- Molecular Weight
- 2,174.6 g/mol
- PubChem ID
- 146675088
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