KPV

KPV Overview

KPV, short for Lys-Pro-Val, is a three-amino-acid peptide corresponding to the C-terminal 11–13 fragment of α-melanocyte-stimulating hormone (α-MSH). In research settings, it is studied as a compact melanocortin-related peptide fragment with relevance to inflammatory signaling, epithelial response models, and mucosal pathway biology.

Mechanism of Action & Applications

KPV is studied for how it influences inflammation-related signaling at the cellular level. Published research has examined KPV in models involving peptide transport through PepT1, epithelial inflammatory responses, and melanocortin-associated pathway biology. This makes it useful in laboratory studies involving mucosal biology, epithelial signaling, immune-pathway research, and broader peptide-mediated inflammatory response models.

Research History

Research interest in KPV grew from work on α-MSH and related melanocortin peptides, where investigators identified the Lys-Pro-Val sequence as an important C-terminal fragment for studying inflammation-related peptide activity. Later studies expanded into epithelial, intestinal, and transport-related models, helping establish KPV as a distinct research peptide rather than only a fragment discussed within α-MSH literature.

Chemical Information

CAS Number

67727-97-3

Molecular Formula

C₁₆H₃₀N₄O₄

Molecular Weight

342.43 g/mol

PubChem ID

125672