CJC-1295 (DAC)

CJC-1295 (DAC) Overview

CJC-1295 (DAC) is a modified analogue of growth hormone-releasing hormone designed for prolonged activity. In research settings, it is used to examine sustained GHRH receptor signaling and the downstream endocrine pathways associated with extended peptide half-life. The “DAC” component refers to the drug affinity complex that allows the peptide to bind endogenous albumin and remain active longer than the non-DAC form.

Mechanism of Action & Applications

CJC-1295 (DAC) is studied for agonist activity at the GHRH receptor. Its DAC modification enables covalent binding to circulating albumin, which extends its half-life and makes it useful in research involving prolonged receptor stimulation, pituitary signaling, and hormone-release dynamics. It is commonly studied in models involving GHRH receptor biology, growth hormone pathway signaling, peptide half-life extension, and albumin-binding peptide design.

Research History

CJC-1295 (DAC) emerged from efforts to create a longer-acting GHRH analogue with improved stability and duration. Published work in the mid-2000s described it as a modified GHRH-based peptide capable of prolonged biological activity through albumin conjugation, distinguishing it from shorter-acting GHRH analogues and from CJC-1295 without DAC.

Chemical Information

CAS Number

446262-90-4

Molecular Formula

C₁₆₅H₂₆₉N₄₇O₄₆

Molecular Weight

3,647.2 g/mol

PubChem ID

56841945

Compound

CJC-1295 (DAC)

Selected quantity

5 MG per vial

Research area

Musculoskeletal & Growth

Intended use

Laboratory research only

Laboratory storage & handling

Form

Lyophilized powder

Short-term

2–8 °C (refrigerated)

Long-term

−20 °C (frozen)

Container

Use the supplied container and follow its label

Lot-specific stability

Not established on this product page

Reconstitution

Consult the applicable research protocol and available lot record

For research use only. Not for human or veterinary use.

A certificate for CJC-1295 (DAC) 5 MG has not been published yet. Records are published per lot as they are received; a missing record is not a test result.

Use the lot number on your vial to locate the corresponding certificate once it is available, or contact support for batch documentation.

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